CCR2 Deficiency Impairs Ly6Clo and Ly6Chi Monocyte Responses in Orientia tsutsugamushi Infection
Orientia (O.) tsutsugamushi, the causative agent of scrub typhus, is a neglected, obligate intracellular bacterium that has a prominent tropism for monocytes and macrophages.Complications often involve the lung, where interstitial pneumonia is a typical finding.The severity of scrub typhus in humans has been linked to altered plasma concentrations